MovDisordV3, Main, Exploration, bibRecord, 001D02

Evidence in favor of Braak staging of Parkinson's disease

Identifieur interne : 001D02 ( Main/Exploration ); précédent : 001D01; suivant : 001D03

Evidence in favor of Braak staging of Parkinson's disease

Auteurs : Dennis W. Dickson [États-Unis] ; Hirotake Uchikado [États-Unis] ; Hiroshige Fujishiro [États-Unis] ; Yoshio Tsuboi [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010.

RBID : ISTEX:7964CE0D2737D14278190578B550391DC53888AA

Descripteurs français

Pascal (Inist)
- Corps Lewy, Maladie de Parkinson, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Female, Humans, Lewy Bodies (metabolism), Lewy Body Disease (metabolism), Lewy Body Disease (pathology), Lewy body, Male, Nervous system diseases, Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease staging, Severity of Illness Index, Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology), alpha-Synuclein (metabolism), neuropathology, α‐synuclein Lewy bodies.
MESH :
- chemical , metabolism : alpha-Synuclein.
- metabolism : Alzheimer Disease, Lewy Bodies, Lewy Body Disease, Parkinson Disease, Supranuclear Palsy, Progressive.
- pathology : Alzheimer Disease, Lewy Body Disease, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Female, Humans, Male, Severity of Illness Index.

Abstract

Recently, Braak and coworkers proposed a pathologic staging scheme for Parkinson disease (PD). In this staging, scheme substantia nigra pathology occurs at midstage disease, while involvement of anterior olfactory nucleus, medulla, and pontine tegmentum occur earlier. In the last stages, Lewy bodies (LBs) involve cortical areas. The general principles of the proposed staging system have been confirmed in several studies of PD, but it does not appear to fit with all LB disorders. We studied the density and distribution of LBs with α‐synuclein immunohistochemistry in normal elderly with incidental LBs (N = 12); progressive supranuclear palsy (PSP) with incidental LBs (N = 18); Lewy body disease (LBD) with minimal or no Alzheimer type pathology (N = 52); LBD with concomitant Alzheimer disease (AD) (N = 84); and cases of AD with amygdala predominant LBs (N = 64). The proportion of cases that fit the PD staging scheme was 67% for incidental LBs; 86% for PSP with LBs; 86% for pure LBD; and 84% for LBD with AD; but only 6% for AD with amygdala predominant LBs. The PD staging scheme is valid, except in the setting of advanced AD. In this situation, LBs may be unrelated to PD and more likely related to factors inherent to AD and the selective vulnerability of the amygdala to both Alzheimer and α‐synuclein pathologies. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/7964CE0D2737D14278190578B550391DC53888AA/fulltext/pdf

DOI: 10.1002/mds.22637

Affiliations:

Le document en format XML

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<term>Lewy Bodies (metabolism)</term>
<term>Lewy Body Disease (metabolism)</term>
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<term>Lewy body</term>
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<term>Nervous system diseases</term>
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<term>Supranuclear Palsy, Progressive (metabolism)</term>
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<term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
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<front><div type="abstract" xml:lang="en">Recently, Braak and coworkers proposed a pathologic staging scheme for Parkinson disease (PD). In this staging, scheme substantia nigra pathology occurs at midstage disease, while involvement of anterior olfactory nucleus, medulla, and pontine tegmentum occur earlier. In the last stages, Lewy bodies (LBs) involve cortical areas. The general principles of the proposed staging system have been confirmed in several studies of PD, but it does not appear to fit with all LB disorders. We studied the density and distribution of LBs with α‐synuclein immunohistochemistry in normal elderly with incidental LBs (N = 12); progressive supranuclear palsy (PSP) with incidental LBs (N = 18); Lewy body disease (LBD) with minimal or no Alzheimer type pathology (N = 52); LBD with concomitant Alzheimer disease (AD) (N = 84); and cases of AD with amygdala predominant LBs (N = 64). The proportion of cases that fit the PD staging scheme was 67% for incidental LBs; 86% for PSP with LBs; 86% for pure LBD; and 84% for LBD with AD; but only 6% for AD with amygdala predominant LBs. The PD staging scheme is valid, except in the setting of advanced AD. In this situation, LBs may be unrelated to PD and more likely related to factors inherent to AD and the selective vulnerability of the amygdala to both Alzheimer and α‐synuclein pathologies. © 2010 Movement Disorder Society</div>
</front>
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<name sortKey="Uchikado, Hirotake" sort="Uchikado, Hirotake" uniqKey="Uchikado H" first="Hirotake" last="Uchikado">Hirotake Uchikado</name>
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Movement Disorders (revue)

Evidence in favor of Braak staging of Parkinson's disease

Evidence in favor of Braak staging of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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